Schematic illustration of nucleic acid detection by the conventional CRISPR assay and the asymmetric CRISPR assay. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-43389-7 Changchun Liu, ...

Tuberculosis (TB) remains one of the leading causes of mortality from a single infectious agent worldwide and continues to pose a major public health ...

The CRISPR/Cas system, known for gene editing, is now revolutionizing molecular diagnostics due to its high specificity and efficiency in recognizing and cleaving target sequences. Cas9, Cas12, and ...

JMIR Publications today featured two new stories in its News and Perspectives section, highlighting a shift toward proactive, ...

New CRISPR approach: HKUST scientists created a DNA-guided CRISPR-Cas12a system that targets RNA, overturning the traditional ...

Originally developed for gene editing, CRISPR-Cas systems have now become powerful molecular diagnostic tools. However, their widespread adoption in diagnostics has relied heavily on traditional ...

Smartphone-based optical imaging and sensing devices are among the next-generation biosensors that have shown great potential to transform the field of point-of-care (POC) diagnostics. With the rapid ...

Researchers at Dana-Farber Cancer Institute have created a CRISPR-based rapid molecular diagnostic for two forms of leukemia that are driven by mutations that involve gene fusions. The technology ...

What’s the breakthrough?: A CRISPR-dCas9 base editing system can permanently switch off essential microbial genes without DNA cleavage, preventing survival outside controlled environments. Why it ...

Overview of CRISPR/Cas system-based tumor molecular diagnostic strategies, including variant gene, protein, and liquid biopsy marker assays and in situ molecular analysis. The CRISPR/Cas system, known ...