Sox9, a master regulator of cartilage formation, switches its target genes dynamically during embryonic limb development instead of following a fixed program, as reported by researchers from Science ...

Researchers have identified modes of Sox9 action during cartilage formation by analyzing big data on Sox9 location, chromatin state, and gene expression over the whole mouse genome. This finding will ...

Following the lead of previous work on mRNA-based vaccines, therapies for spinal cord injuries and more, the method relies upon mineral-coated microparticles to deliver mRNA that encodes for ...

Cartilage is largely composed of a single type of cells, called chondrocytes and various types of extracellular matrix proteins including highly sulfated macromolecule proteoglycans, small ...

An origami scaffold uses electrical repair cues and light-triggered heating to promote cartilage formation while limiting ...

In patients with severe osteoarthritis, cartilage can wear so thin that joints essentially transform into bone on bone — without a cushion between. A new therapy that uses synthetic nanofibers to ...

A recent article in Engineering describes the development of a protein-based nanocomposite hydrogel designed to deliver two therapeutic agents—dexamethasone (Dex) and kartogenin (KGN)—to support ...