In a demonstration that could help pave the way for gene therapies with fewer side effects, several human cell types have been genetically modified with protein nanoparticles designed at University of ...

Companies are adopting diverse approaches to reducing unwanted toxicities associated with cell and gene therapy.

A new platform identifies which genes drive particle assembly to engineer cells that yield more potent delivery vehicles.

Cells throughout the body work together like singers in a choir to keep us healthy, as long as they work in perfect harmony. If any cells are off key, that harmony can be disrupted, with far-reaching ...

Cells contain a blueprint in the form of DNA that dictates what they can make. This blueprint is converted into a message, or mRNA, which is then converted into protein. Although DNA remains the same ...

This review explains how glucose scarcity, lipid disruption, amino acid deprivation, and toxic metabolites weaken CAR-T cells ...

Researchers at Northwestern University have built a new type of nanoparticle that triples the efficiency of CRISPR gene editing across multiple human cell types, a result that could reshape how ...