For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...

Glucose is life's main energy source. But a new study reveals a surprising role as a master manipulator of tissue maturation, hinting at its importance in diabetes and cancer. The sugar glucose, which ...

As stem cells decide who they want to become, they embark on a journey of gradual differentiation into their final cell fate. This transformation is traditionally depicted by the Waddington landscape ...

Northwestern Medicine scientists have identified the cellular mechanisms that cause immune cells to differentiate and ultimately lose function during viral infection, findings that could improve ...

The sugar glucose, which is the main source of energy in almost every living cell, has been revealed in a Stanford Medicine study to also be a master regulator of tissue differentiation - the process ...

Diabetes is a worldwide health crisis. Estimates in 2024 revealed 537 million adults aged 20 to 79 are affected by diabetes, and this number is projected to increase to 643 million by 2030. The ...