Neurons in the human brain play a crucial role in appetite, satiety, and metabolism. Research has revealed more about the neuronal circuits that are involved in these processes, as well as obesity.

Leptin is a hormone – a chemical messenger that helps different body parts work together. Leptin sends a signal to your brain that helps you feel full and less interested in food. You may hear it ...

Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as a predominant chronic liver condition globally, intricately linked with obesity, type 2 diabetes (T2DM), and metabolic ...

Anil Oza is a general assignment reporter at STAT focused on the NIH and health equity. You can reach him on Signal at aniloza.16. The hormone leptin was discovered 30 years ago to much fanfare.

Leptin is a hormone that comes from fat cells. It helps control food intake by sending signals about hunger to the hypothalamus in the brain. This process regulates appetite. Leptin regulates energy ...

Hormone absence or inactivity is common in congenital disease, but hormone antagonism remains controversial. Here, we characterize two novel homozygous leptin variants that yielded antagonistic ...

Most obese patients grow resistant to satiety signals from the hormone leptin. A new study shows that leptin sensitivity can be restored in mice, leading to weight loss. Worldwide obesity rates have ...

Three decades ago, in a lab at The Rockefeller University, New York City, Jeffrey Friedman, MD, PhD, observed a paradox that would forever change our understanding of obesity. His subjects, a rare ...

NEW YORK (Reuters Health) - Studies in obese mice suggest that a sensor in the brain that normally detects the fat hormone leptin -- causing a series of events that keep energy balance in check -- ...

Loss of a protein essential for degrading mRNA from the forebrain of mice leads to increased appetite and the onset of obesity, a new study finds. Obesity is an increasingly serious public health ...