The transcription factor p53 is the most frequently inactivated tumour suppressor in cancer. Approaches to restore its wild-type function are challenging and have not led to approved drugs. An ...
The tumor suppressor protein p53 plays a critical role in preventing cancer by regulating cell cycle, apoptosis, and genomic stability. However, mutations in the P53 gene are found in over 50% of ...
A team of researchers at VCU Massey Comprehensive Cancer Center has identified a new pathway through which mutations in the tumor suppressor p53 gene—found very frequently in human tumors—hijack DNA ...
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