Ten structures of URAT1 obtained by scientists provide a deep understanding of the mechanism of urate transport to guide gout therapeutic design. Scientists at St. Jude Children's Research Hospital ...

Prostaglandin E 2 (PGE 2), a bioactive lipid derived from arachidonic acid, mediates a broad range of physiological processes through four G protein-coupled receptor (GPCR) subtypes: EP1–EP4. While ...

Salk Institute researchers, in collaboration with National Institutes of Health (NIH) scientists, have discovered the molecular mechanisms by which human immunodeficiency virus (HIV) becomes resistant ...

Understanding the microstructure of materials such as rubber and thermoplastics can help design materials’ macrostructure properties. Microscopy can provide useful information in designing soft ...

Chemerin is a key adipokine—a signaling protein released by adipose tissue—that regulates lipid metabolism and insulin sensitivity and thus is involved in many metabolic diseases such as obesity and ...